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Mechanistic Insights into Hsp104 Potentiation

Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Torrente, Mariana P., Chuang, Edward, Noll, Megan M., Jackrel, Meredith E., Go, Michelle S., Shorter, James
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777845/
https://ncbi.nlm.nih.gov/pubmed/26747608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707976
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