Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro

Complement factor H (FH) inhibits complement activation and interacts with glomerular endothelium via its complement control protein domains 19 and 20, which also recognize heparan sulfate (HS). Abnormalities in FH are associated with the renal diseases atypical hemolytic uremic syndrome and dense d...

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Vydáno v:J Biol Chem
Hlavní autoři: Loeven, Markus A., Rops, Angelique L., Lehtinen, Markus J., van Kuppevelt, Toin H., Daha, Mohamed R., Smith, Richard J., Bakker, Marinka, Berden, Jo H., Rabelink, Ton J., Jokiranta, T. Sakari, van der Vlag, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777835/
https://ncbi.nlm.nih.gov/pubmed/26728463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702506
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