Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro

Complement factor H (FH) inhibits complement activation and interacts with glomerular endothelium via its complement control protein domains 19 and 20, which also recognize heparan sulfate (HS). Abnormalities in FH are associated with the renal diseases atypical hemolytic uremic syndrome and dense d...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Loeven, Markus A., Rops, Angelique L., Lehtinen, Markus J., van Kuppevelt, Toin H., Daha, Mohamed R., Smith, Richard J., Bakker, Marinka, Berden, Jo H., Rabelink, Ton J., Jokiranta, T. Sakari, van der Vlag, Johan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777835/
https://ncbi.nlm.nih.gov/pubmed/26728463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.702506
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