Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

Diabetic nephropathy (DN) is the leading cause of CKD in the Western world. Endothelin receptor antagonists have emerged as a novel treatment for DN, but the mechanisms underlying the protective effect remain unknown. We previously showed that both heparanase and endothelin-1 are essential for the d...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Garsen, Marjolein, Lenoir, Olivia, Rops, Angelique L.W.M.M., Dijkman, Henry B., Willemsen, Brigith, van Kuppevelt, Toin H., Rabelink, Ton J., Berden, Jo H.M., Tharaux, Pierre-Louis, van der Vlag, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2016
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118481/
https://ncbi.nlm.nih.gov/pubmed/27026367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015091070
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