Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Lo...

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Detaylı Bibliyografya
Asıl Yazarlar: Gil, Natali, Goldberg, Rachel, Neuman, Tzahi, Garsen, Marjolein, Zcharia, Eyal, Rubinstein, Ariel M., van Kuppevelt, Toin, Meirovitz, Amichay, Pisano, Claudio, Li, Jin-Ping, van der Vlag, Johan, Vlodavsky, Israel, Elkin, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2012
Konular:
Complications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237641/
https://ncbi.nlm.nih.gov/pubmed/22106160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1024
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