Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Lo...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gil, Natali, Goldberg, Rachel, Neuman, Tzahi, Garsen, Marjolein, Zcharia, Eyal, Rubinstein, Ariel M., van Kuppevelt, Toin, Meirovitz, Amichay, Pisano, Claudio, Li, Jin-Ping, van der Vlag, Johan, Vlodavsky, Israel, Elkin, Michael
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Diabetes Association 2012
Aiheet:
Complications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237641/
https://ncbi.nlm.nih.gov/pubmed/22106160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1024
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