Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Lo...

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Autores principales: Gil, Natali, Goldberg, Rachel, Neuman, Tzahi, Garsen, Marjolein, Zcharia, Eyal, Rubinstein, Ariel M., van Kuppevelt, Toin, Meirovitz, Amichay, Pisano, Claudio, Li, Jin-Ping, van der Vlag, Johan, Vlodavsky, Israel, Elkin, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2012
Materias:
Complications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237641/
https://ncbi.nlm.nih.gov/pubmed/22106160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1024
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