Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal permselectivity of glomerular basement membrane (GBM) plays an important role in DN pathogenesis. Heparanase is the predominant enzyme that degrades heparan sulfate (HS), the main polysaccharide of the GBM. Lo...

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Main Authors: Gil, Natali, Goldberg, Rachel, Neuman, Tzahi, Garsen, Marjolein, Zcharia, Eyal, Rubinstein, Ariel M., van Kuppevelt, Toin, Meirovitz, Amichay, Pisano, Claudio, Li, Jin-Ping, van der Vlag, Johan, Vlodavsky, Israel, Elkin, Michael
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2012
Fag:
Complications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237641/
https://ncbi.nlm.nih.gov/pubmed/22106160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1024
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