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Identification of the substrate access portal of 5-Lipoxygenase
The overproduction of inflammatory lipid mediators derived from arachidonic acid contributes to asthma and cardiovascular diseases, among other pathologies. Consequently, the enzyme that initiates the synthesis of pro-inflammatory leukotrienes, 5-lipoxygenase (5-LOX), is a target for drug design. Th...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777300/ https://ncbi.nlm.nih.gov/pubmed/26427761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00930 |
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