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Identification of the substrate access portal of 5-Lipoxygenase

The overproduction of inflammatory lipid mediators derived from arachidonic acid contributes to asthma and cardiovascular diseases, among other pathologies. Consequently, the enzyme that initiates the synthesis of pro-inflammatory leukotrienes, 5-lipoxygenase (5-LOX), is a target for drug design. Th...

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書誌詳細
出版年:Biochemistry
主要な著者: Mitra, Sunayana, Bartlett, Sue G., Newcomer, Marcia E.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777300/
https://ncbi.nlm.nih.gov/pubmed/26427761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00930
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