Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663

The enzyme 5-lipoxygenase (5-LOX) initiates biosynthesis of the proinflammatory leukotriene lipid mediators and, together with 15-LOX, is also required for synthesis of the anti-inflammatory lipoxins. The catalytic activity of 5-LOX is regulated through multiple mechanisms, including Ca(2+)-targeted...

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Autores principales: Gilbert, Nathaniel C., Rui, Zhe, Neau, David B., Waight, Maria T., Bartlett, Sue G., Boeglin, William E., Brash, Alan R., Newcomer, Marcia E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405276/
https://ncbi.nlm.nih.gov/pubmed/22516296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-205286
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