Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

Target-specific, mechanism-oriented in vitro assays post a promising alternative to traditional animal toxicology studies. Here we report the first comprehensive analysis of the Tox21 effort, a large-scale in vitro toxicity screening of chemicals. We test ∼10,000 chemicals in triplicates at 15 conce...

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Published in:Nat Commun
Main Authors: Huang, Ruili, Xia, Menghang, Sakamuru, Srilatha, Zhao, Jinghua, Shahane, Sampada A., Attene-Ramos, Matias, Zhao, Tongan, Austin, Christopher P., Simeonov, Anton
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777217/
https://ncbi.nlm.nih.gov/pubmed/26811972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10425
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