Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage

Cytotoxicity is a commonly used in vitro endpoint for evaluating chemical toxicity. In support of the U.S. Tox21 screening program, the cytotoxicity of ~10K chemicals was interrogated at 0, 8, 16, 24, 32, & 40 hours of exposure in a concentration dependent fashion in two cell lines (HEK293, HepG...

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Foilsithe in:PLoS One
Main Authors: Hsieh, Jui-Hua, Huang, Ruili, Lin, Ja-An, Sedykh, Alexander, Zhao, Jinghua, Tice, Raymond R., Paules, Richard S., Xia, Menghang, Auerbach, Scott S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439695/
https://ncbi.nlm.nih.gov/pubmed/28531190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177902
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