A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase

Trypanosoma brucei PRMT7 (TbPRMT7) is a protein arginine methyltransferase (PRMT) that strictly monomethylates various substrates, thus classifying it as a type III PRMT. However, the molecular basis of its unique product specificity has remained elusive. Here, we present the structure of TbPRMT7 in...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Debler, Erik W., Jain, Kanishk, Warmack, Rebeccah A., Feng, You, Clarke, Steven G., Blobel, Günter, Stavropoulos, Pete
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776506/
https://ncbi.nlm.nih.gov/pubmed/26858449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525783113
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