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Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures

In the family of protein arginine methyltransferases (PRMTs) that predominantly generate either asymmetric or symmetric dimethylarginine (SDMA), PRMT7 is unique in producing solely monomethylarginine (MMA) products. The type of methylation on histones and other proteins dictates changes in gene expr...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Jain, Kanishk, Warmack, Rebeccah A., Debler, Erik W., Hadjikyriacou, Andrea, Stavropoulos, Peter, Clarke, Steven G.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000077/
https://ncbi.nlm.nih.gov/pubmed/27387499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740399
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