Substrate Specificity of Human Protein Arginine Methyltransferase 7 (PRMT7): THE IMPORTANCE OF ACIDIC RESIDUES IN THE DOUBLE E LOOP

Protein arginine methyltransferase 7 (PRMT7) methylates arginine residues on various protein substrates and is involved in DNA transcription, RNA splicing, DNA repair, cell differentiation, and metastasis. The substrate sequences it recognizes in vivo and the enzymatic mechanism behind it, however,...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Feng, You, Hadjikyriacou, Andrea, Clarke, Steven G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239614/
https://ncbi.nlm.nih.gov/pubmed/25294873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609271
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