Substrate Specificity of Human Protein Arginine Methyltransferase 7 (PRMT7): THE IMPORTANCE OF ACIDIC RESIDUES IN THE DOUBLE E LOOP

Protein arginine methyltransferase 7 (PRMT7) methylates arginine residues on various protein substrates and is involved in DNA transcription, RNA splicing, DNA repair, cell differentiation, and metastasis. The substrate sequences it recognizes in vivo and the enzymatic mechanism behind it, however,...

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Vydáno v:J Biol Chem
Hlavní autoři: Feng, You, Hadjikyriacou, Andrea, Clarke, Steven G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239614/
https://ncbi.nlm.nih.gov/pubmed/25294873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609271
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