Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design

Boronic acid transition state inhibitors (BATSIs) are competitive, reversible β-lactamase inhibitors (BLIs). In this study, a series of BATSIs with selectively modified regions (R1, R2, and amide group) were strategically designed and tested against representative class A β-lactamases of Klebsiella...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Rojas, Laura J., Taracila, Magdalena A., Papp-Wallace, Krisztina M., Bethel, Christopher R., Caselli, Emilia, Romagnoli, Chiara, Winkler, Marisa L., Spellberg, Brad, Prati, Fabio, Bonomo, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2016
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776006/
https://ncbi.nlm.nih.gov/pubmed/26729496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02641-15
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