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Variants of β-Lactamase KPC-2 That Are Resistant to Inhibition by Avibactam
KPC-2 is the most prevalent class A carbapenemase in the world. Previously, KPC-2 was shown to hydrolyze the β-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam. In addition, substitutions at amino acid position R220 in the KPC-2 β-lactamase increased resistance to clavulanic acid. A n...
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| Pubblicato in: | Antimicrob Agents Chemother |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468660/ https://ncbi.nlm.nih.gov/pubmed/25666153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04406-14 |
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