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Variants of β-Lactamase KPC-2 That Are Resistant to Inhibition by Avibactam

KPC-2 is the most prevalent class A carbapenemase in the world. Previously, KPC-2 was shown to hydrolyze the β-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam. In addition, substitutions at amino acid position R220 in the KPC-2 β-lactamase increased resistance to clavulanic acid. A n...

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Papp-Wallace, Krisztina M., Winkler, Marisa L., Taracila, Magdalena A., Bonomo, Robert A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468660/
https://ncbi.nlm.nih.gov/pubmed/25666153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04406-14
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