Exposing a β-Lactamase “Twist”: the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI β-Lactamase

Around the world, Burkholderia spp. are emerging as pathogens highly resistant to β-lactam antibiotics, especially ceftazidime. Clinical variants of Burkholderia pseudomallei possessing the class A β-lactamase PenI with substitutions at positions C69 and P167 are known to demonstrate ceftazidime res...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Papp-Wallace, Krisztina M., Becka, Scott A., Taracila, Magdalena A., Winkler, Marisa L., Gatta, Julian A., Rholl, Drew A., Schweizer, Herbert P., Bonomo, Robert A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750712/
https://ncbi.nlm.nih.gov/pubmed/26596949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02073-15
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