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Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen

The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (BCC) infections. Regrettably, BCC organisms are highly resistant to most antibiotics, including polymyxins; ceftazidime and trime...

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Bibliografische gegevens
Gepubliceerd in:Antimicrob Agents Chemother
Hoofdauteurs: Papp-Wallace, Krisztina M., Becka, Scott A., Taracila, Magdalena A., Zeiser, Elise T., Gatta, Julian A., LiPuma, John J., Bonomo, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278747/
https://ncbi.nlm.nih.gov/pubmed/27872073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01941-16
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