Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen

The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (BCC) infections. Regrettably, BCC organisms are highly resistant to most antibiotics, including polymyxins; ceftazidime and trime...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Papp-Wallace, Krisztina M., Becka, Scott A., Taracila, Magdalena A., Zeiser, Elise T., Gatta, Julian A., LiPuma, John J., Bonomo, Robert A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278747/
https://ncbi.nlm.nih.gov/pubmed/27872073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01941-16
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