Exploring the Role of the Ω-Loop in the Evolution of Ceftazidime Resistance in the PenA β-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen

The unwelcome evolution of resistance to the advanced generation cephalosporin antibiotic, ceftazidime is hindering the effective therapy of Burkholderia cepacia complex (BCC) infections. Regrettably, BCC organisms are highly resistant to most antibiotics, including polymyxins; ceftazidime and trime...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Papp-Wallace, Krisztina M., Becka, Scott A., Taracila, Magdalena A., Zeiser, Elise T., Gatta, Julian A., LiPuma, John J., Bonomo, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278747/
https://ncbi.nlm.nih.gov/pubmed/27872073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01941-16
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