Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030

Resistance to expanded-spectrum cephalosporins and carbapenems has rendered certain strains of Klebsiella pneumoniae the most problematic pathogens infecting patients in the hospital and community. This broad-spectrum resistance to β-lactamases emerges in part via the expression of KPC-2 and SHV-1 β...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Nguyen, Nhu Q., Krishnan, Nikhil P., Rojas, Laura J., Prati, Fabio, Caselli, Emilia, Romagnoli, Chiara, Bonomo, Robert A., van den Akker, Focco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775972/
https://ncbi.nlm.nih.gov/pubmed/26729491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02643-15
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