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Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study

β-Lactamase inhibition is an important clinical strategy in overcoming β-lactamase-mediated resistance to β-lactam antibiotics in Gram negative bacteria. A new β-lactamase inhibitor, avibactam, is entering the clinical arena and promising to be a major step forward in our antibiotic armamentarium. A...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Krishnan, Nikhil P., Nguyen, Nhu Q., Papp-Wallace, Krisztina M., Bonomo, Robert A., van den Akker, Focco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560403/
https://ncbi.nlm.nih.gov/pubmed/26340563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136813
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