Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers under Chloroquine Prophylaxis: A Randomized Controlled Trial

Immunization of volunteers under chloroquine prophylaxis by bites of Plasmodium falciparum sporozoite (PfSPZ)–infected mosquitoes induces > 90% protection against controlled human malaria infection (CHMI). We studied intradermal immunization with cryopreserved, infectious PfSPZ in volunteers taki...

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Udgivet i:Am J Trop Med Hyg
Main Authors: Bastiaens, Guido J. H., van Meer, Maurits P. A., Scholzen, Anja, Obiero, Joshua M., Vatanshenassan, Mansoureh, van Grinsven, Tim, Kim Lee Sim, B., Billingsley, Peter F., James, Eric R., Gunasekera, Anusha, Bijker, Else M., van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, Graumans, Wouter, Hermsen, Cornelus C., de Mast, Quirijn, van der Ven, André J. A. M., Hoffman, Stephen L., Sauerwein, Robert W.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Tropical Medicine and Hygiene 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775905/
https://ncbi.nlm.nih.gov/pubmed/26711509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.15-0621
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