Sporozoite Immunization of Human Volunteers under Mefloquine Prophylaxis Is Safe, Immunogenic and Protective: A Double-Blind Randomized Controlled Clinical Trial

Immunization of healthy volunteers with chloroquine ChemoProphylaxis and Sporozoites (CPS-CQ) efficiently and reproducibly induces dose-dependent and long-lasting protection against homologous Plasmodium falciparum challenge. Here, we studied whether chloroquine can be replaced by mefloquine, which...

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Publicado en:PLoS One
Main Authors: Bijker, Else M., Schats, Remko, Obiero, Joshua M., Behet, Marije C., van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, Graumans, Wouter, van Lieshout, Lisette, Bastiaens, Guido J. H., Teelen, Karina, Hermsen, Cornelus C., Scholzen, Anja, Visser, Leo G., Sauerwein, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232459/
https://ncbi.nlm.nih.gov/pubmed/25396417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112910
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