PD-1 blockade expands intratumoral T memory cells

Tumor responses to PD-1 blockade therapy are mediated by T cells, which we characterized in 102 tumor biopsies obtained from 53 patients treated with pembrolizumab, an antibody to PD-1. Biopsies were dissociated and single cell infiltrates were analyzed by multicolor flow cytometry using two computa...

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Udgivet i:Cancer Immunol Res
Main Authors: Ribas, Antoni, Shin, Daniel Sanghoon, Zaretsky, Jesse, Frederiksen, Juliet, Cornish, Andrew, Avramis, Earl, Seja, Elizabeth, Kivork, Christine, Siebert, Janet, Kaplan-Lefko, Paula, Wang, Xiaoyan, Chmielowski, Bartosz, Glaspy, John A., Tumeh, Paul C., Chodon, Thinle, Pe’er, Dana, Comin-Anduix, Begoña
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775381/
https://ncbi.nlm.nih.gov/pubmed/26787823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0210
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