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The impact of ex vivo clinical grade activation protocols on human T cell phenotype and function for the generation of genetically modified cells for adoptive cell transfer therapy

Optimized conditions for the ex vivo activation, genetic manipulation, and expansion of human lymphocytes for adoptive cell therapy (ACT) may lead to protocols that maximize their in vivo function. We analyzed the effects of four clinical grade activation and expansion protocols over three weeks on...

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Main Authors: Tumeh, Paul C., Koya, Richard C., Chodon, Thinle, Graham, Nicholas A., Graeber, Thomas G., Comin-Anduix, Begoña, Ribas, Antoni
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114626/
https://ncbi.nlm.nih.gov/pubmed/20842061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181f1d644
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