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Uncoupling Catalytic and Binding Functions in the cAMP-Dependent Protein Kinase A
The canonical function of kinases is to transfer a phosphoryl group to substrates, initiating a signaling cascade; while their non-canonical role is to bind other kinases or substrates, acting as scaffolds, competitors, and signal integrators. Here, we show how to uncouple kinases dual function by t...
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| Veröffentlicht in: | Structure |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4775281/ https://ncbi.nlm.nih.gov/pubmed/26833386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.11.016 |
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