Synchronous Opening and Closing Motions are Essential for cAMP-Dependent Protein Kinase A Signaling

Conformational fluctuations play a central role in enzymatic catalysis. However, it is not clear how the rates and the coordination of the motions affect the different catalytic steps. Here, we used NMR spectroscopy to analyze the conformational fluctuations of the catalytic subunit of the cAMP-depe...

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Veröffentlicht in:Structure
Hauptverfasser: Srivastava, Atul K., McDonald, Leanna R., Cembran, Alessandro, Kim, Jonggul, Masterson, Larry R., McClendon, Christopher L., Taylor, Susan S., Veglia, Gianluigi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255147/
https://ncbi.nlm.nih.gov/pubmed/25458836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.010
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