Synchronous Opening and Closing Motions are Essential for cAMP-Dependent Protein Kinase A Signaling

Conformational fluctuations play a central role in enzymatic catalysis. However, it is not clear how the rates and the coordination of the motions affect the different catalytic steps. Here, we used NMR spectroscopy to analyze the conformational fluctuations of the catalytic subunit of the cAMP-depe...

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Pubblicato in:Structure
Autori principali: Srivastava, Atul K., McDonald, Leanna R., Cembran, Alessandro, Kim, Jonggul, Masterson, Larry R., McClendon, Christopher L., Taylor, Susan S., Veglia, Gianluigi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255147/
https://ncbi.nlm.nih.gov/pubmed/25458836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.010
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