c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia

BACKGROUND: Genomic instability and clonal evolution are hallmarks of progressing chronic myeloid leukemia (CML). Recently, we have shown that clonal evolution and blast crisis correlate with altered expression and activity of Separase, a cysteine endopeptidase that is a mitotic key player in chromo...

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Publicado en:Biomark Res
Autores principales: Prinzhorn, Wiltrud, Stehle, Michael, Kleiner, Helga, Ruppenthal, Sabrina, Müller, Martin C., Hofmann, Wolf-Karsten, Fabarius, Alice, Seifarth, Wolfgang
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774018/
https://ncbi.nlm.nih.gov/pubmed/26937281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40364-016-0059-2
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