Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

Unbalanced (major route) additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukemia (CML) indicate an increased risk of progression and shorter survival. Moreover, newly arising ACA under imatinib treatment and clonal evolution are considered features of acceleration and defin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Haaß, Wiltrud, Kleiner, Helga, Weiß, Christel, Haferlach, Claudia, Schlegelberger, Brigitte, Müller, Martin C., Hehlmann, Rüdiger, Hofmann, Wolf-Karsten, Fabarius, Alice, Seifarth, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472749/
https://ncbi.nlm.nih.gov/pubmed/26087013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129648
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