Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy

Unbalanced (major route) additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukemia (CML) indicate an increased risk of progression and shorter survival. Moreover, newly arising ACA under imatinib treatment and clonal evolution are considered features of acceleration and defin...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Haaß, Wiltrud, Kleiner, Helga, Weiß, Christel, Haferlach, Claudia, Schlegelberger, Brigitte, Müller, Martin C., Hehlmann, Rüdiger, Hofmann, Wolf-Karsten, Fabarius, Alice, Seifarth, Wolfgang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472749/
https://ncbi.nlm.nih.gov/pubmed/26087013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0129648
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