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Separase activity distribution can be a marker of major molecular response and proliferation of CD34(+) cells in TKI-treated chronic myeloid leukemia patients

Separase, a cysteine endopeptidase, is a key player in mitotic sister chromatid separation, replication fork dynamics, and DNA repair. Aberrant expression and/or altered separase proteolytic activity are associated with aneuploidy, tumorigenesis, and disease progression. Since genomic instability an...

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Detalhes bibliográficos
Publicado no:Ann Hematol
Main Authors: Spiess, Birgit, Kleiner, Helga, Flach, Johanna, Fabarius, Alice, Saussele, Susanne, Hofmann, Wolf-Karsten, Seifarth, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7196950/
https://ncbi.nlm.nih.gov/pubmed/32253454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-020-04007-4
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