Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

The lack of appropriate mouse models is likely one of the reasons of a limited translational success rate of therapeutic vaccines against cervical cancer, as rapidly growing ectopic tumours are commonly used for preclinical studies. In this work, we demonstrate that the tumour microenvironment of TC...

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Pubblicato in:Sci Rep
Autori principali: Bialkowski, Lukasz, van Weijnen, Alexia, Van der Jeught, Kevin, Renmans, Dries, Daszkiewicz, Lidia, Heirman, Carlo, Stangé, Geert, Breckpot, Karine, Aerts, Joeri L., Thielemans, Kris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773884/
https://ncbi.nlm.nih.gov/pubmed/26931556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22509
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