Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(−/−) (C57BL/6) Mice

We evaluated normal tissue specific radioprotection of the oral cavity in radiosensitive Fanconi Anemia (FA) Fancd2(−/−)mice with orally established tumors using mitochondrial-targeted GS-nitroxide (JP4-039). Adult (10–12 weeks old) Fancd2(+/+), Fancd2(+/−) and Fancd2(−/−) mice (C57BL/6 background)...

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Vydáno v:Radiat Res
Hlavní autoři: Shinde, Ashwin, Berhane, Hebist, Rhieu, Byung Han, Kalash, Ronny, Xu, Karen, Goff, Julie, Epperly, Michael W., Franicola, Darcy, Zhang, Xichen, Dixon, Tracy, Shields, Donna, Wang, Hong, Wipf, Peter, Parmar, Kalindi, Guinan, Eva, Kagan, Valerian, Tyurin, Vladimir, Ferris, Robert L., Zhang, Xiaolan, Li, Song, Greenberger, Joel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773657/
https://ncbi.nlm.nih.gov/pubmed/26789701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14035.1
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