Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(−/−) (C57BL/6) Mice

We evaluated normal tissue specific radioprotection of the oral cavity in radiosensitive Fanconi Anemia (FA) Fancd2(−/−)mice with orally established tumors using mitochondrial-targeted GS-nitroxide (JP4-039). Adult (10–12 weeks old) Fancd2(+/+), Fancd2(+/−) and Fancd2(−/−) mice (C57BL/6 background)...

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Detalhes bibliográficos
Publicado no:Radiat Res
Main Authors: Shinde, Ashwin, Berhane, Hebist, Rhieu, Byung Han, Kalash, Ronny, Xu, Karen, Goff, Julie, Epperly, Michael W., Franicola, Darcy, Zhang, Xichen, Dixon, Tracy, Shields, Donna, Wang, Hong, Wipf, Peter, Parmar, Kalindi, Guinan, Eva, Kagan, Valerian, Tyurin, Vladimir, Ferris, Robert L., Zhang, Xiaolan, Li, Song, Greenberger, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773657/
https://ncbi.nlm.nih.gov/pubmed/26789701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14035.1
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