Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2(−/−) (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039

The altered DNA damage response pathway in patients with Fanconi anemia (FA) may increase the toxicity of clinical radiotherapy. We quantitated oral cavity mucositis in irradiated Fanconi anemia Fancd2(−/−) mice, comparing this to Fancd2(+/−) and Fancd2(+/+) mice, and we measured distant bone marrow...

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Hauptverfasser: Berhane, Hebist, Shinde, Ashwin, Kalash, Ronny, Xu, Karen, Epperly, Michael W., Goff, Julie, Franicola, Darcy, Zhang, Xichen, Dixon, Tracy, Shields, Donna, Wang, Hong, Wipf, Peter, Li, Song, Gao, Xiang, Greenberger, Joel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101533/
https://ncbi.nlm.nih.gov/pubmed/24932534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR13633.1
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