CATALYTIC DETOXIFICATION OF NERVE AGENT AND PESTICIDE ORGANOPHOSPHATES BY BUTYRYLCHOLINESTERASE ASSISTED WITH NON-PYRIDINIUM OXIMES

We present here a comprehensive in vitro, ex vivo and in vivo study on hydrolytic detoxification of nerve agent and pesticide organophosphates (OPs) catalyzed by purified human butyrylcholinesterase (hBChE) in combination with novel non-pyridinium oxime reactivators. We identified 2-trimethylammonio...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Radić, Zoran, Dale, Trevor, Kovarik, Zrinka, Berend, Suzana, Garcia, Edzna, Zhang, Limin, Amitai, Gabriel, Green, Carol, Radić, Božica, Duggan, Brendan M., Ajami, Dariush, Rebek, Julius, Taylor, Palmer
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772673/
https://ncbi.nlm.nih.gov/pubmed/23216060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20121612
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