TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. H...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Genome Res
Autores principales: Krell, Jonathan, Stebbing, Justin, Carissimi, Claudia, Dabrowska, Aleksandra F., de Giorgio, Alexander, Frampton, Adam E., Harding, Victoria, Fulci, Valerio, Macino, Giuseppe, Colombo, Teresa, Castellano, Leandro
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772015/
https://ncbi.nlm.nih.gov/pubmed/26701625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.191759.115
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares