Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR

MicroRNA 26a (miR-26a) reduces cell viability in several cancers, indicating that miR-26a could be used as a therapeutic option in patients. We demonstrate that miR-26a not only inhibits G1-S cell cycle transition and promotes apoptosis, as previously described, but also regulates multiple cell cycl...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Castellano, Leandro, Dabrowska, Aleksandra, Pellegrino, Loredana, Ottaviani, Silvia, Cathcart, Paul, Frampton, Adam E., Krell, Jonathan, Stebbing, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416844/
https://ncbi.nlm.nih.gov/pubmed/28126920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx022
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