TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. H...

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Publicat a:Genome Res
Autors principals: Krell, Jonathan, Stebbing, Justin, Carissimi, Claudia, Dabrowska, Aleksandra F., de Giorgio, Alexander, Frampton, Adam E., Harding, Victoria, Fulci, Valerio, Macino, Giuseppe, Colombo, Teresa, Castellano, Leandro
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772015/
https://ncbi.nlm.nih.gov/pubmed/26701625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.191759.115
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