TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. H...

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Foilsithe in:Genome Res
Main Authors: Krell, Jonathan, Stebbing, Justin, Carissimi, Claudia, Dabrowska, Aleksandra F., de Giorgio, Alexander, Frampton, Adam E., Harding, Victoria, Fulci, Valerio, Macino, Giuseppe, Colombo, Teresa, Castellano, Leandro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2016
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772015/
https://ncbi.nlm.nih.gov/pubmed/26701625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.191759.115
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