TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. H...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Krell, Jonathan, Stebbing, Justin, Carissimi, Claudia, Dabrowska, Aleksandra F., de Giorgio, Alexander, Frampton, Adam E., Harding, Victoria, Fulci, Valerio, Macino, Giuseppe, Colombo, Teresa, Castellano, Leandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772015/
https://ncbi.nlm.nih.gov/pubmed/26701625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.191759.115
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