Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

Activation of neuronal nitric oxide synthase, and consequent production of nitric oxide (NO), contributes to spinal hyperexcitability and enhanced pain sensation. All NOS isoforms are inhibited endogenously by asymmetric dimethylarginine, which itself is metabolised by dimethylarginine dimethylamino...

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Bibliographische Detailangaben
Veröffentlicht in:Pain
Hauptverfasser: D'Mello, Richard, Sand, Claire A., Pezet, Sophie, Leiper, James M., Gaurilcikaite, Egle, McMahon, Stephen B., Dickenson, Anthony H., Nandi, Manasi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wolters Kluwer 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770343/
https://ncbi.nlm.nih.gov/pubmed/26098438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000269
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