Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity

Activation of neuronal nitric oxide synthase, and consequent production of nitric oxide (NO), contributes to spinal hyperexcitability and enhanced pain sensation. All NOS isoforms are inhibited endogenously by asymmetric dimethylarginine, which itself is metabolised by dimethylarginine dimethylamino...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: D'Mello, Richard, Sand, Claire A., Pezet, Sophie, Leiper, James M., Gaurilcikaite, Egle, McMahon, Stephen B., Dickenson, Anthony H., Nandi, Manasi
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770343/
https://ncbi.nlm.nih.gov/pubmed/26098438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000269
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