Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas

Solid tumors have acidic extracellular pH (pH(e)) but near neutral intracellular pH (pH(i)). Because acidic pH(e) milieu is conducive to tumor growth and builds resistance to therapy, simultaneous mapping of pH(e) inside and outside the tumor (i.e., intratumoral-peritumoral pH(e) gradient) fulfills...

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Bibliographic Details
Published in:	NMR Biomed
Main Authors:	Coman, Daniel, Huang, Yuegao, Rao, Jyotsna U., De Feyter, Henk M., Rothman, Douglas L., Juchem, Christoph, Hyder, Fahmeed
Format:	Artigo
Language:	Inglês
Published:	2016
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4769673/ https://ncbi.nlm.nih.gov/pubmed/26752688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.3466
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Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas

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