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A Dynamic Search Process Underlies MicroRNA Targeting

Argonaute proteins play a central role in mediating post-transcriptional gene regulation by microRNAs (miRNAs). Argonautes use the nucleotide sequences in miRNAs as guides for identifying target messenger RNAs for repression. Here we used single-molecule FRET to directly visualize how human Argonaut...

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Udgivet i:Cell
Main Authors: Chandradoss, Stanley D., Schirle, Nicole T., Szczepaniak, Malwina, MacRae, Ian J., Joo, Chirlmin
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768356/
https://ncbi.nlm.nih.gov/pubmed/26140593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.032
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