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Robust differential microRNA targeting driven by supplementary interactions in vitro

Complementarity to the microRNA (miRNA) seed region has long been recognized as the primary determinant in target recognition by the Argonaute-miRNA complex. Recently, we reported that pairing to miRNA 3′-supplementary region (nucleotides 13–16) can increase target affinity by more than an order of...

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Bibliografiset tiedot
Julkaisussa:RNA
Päätekijät: Xiao, Yao, MacRae, Ian J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961540/
https://ncbi.nlm.nih.gov/pubmed/31732536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072264.119
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