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Robust differential microRNA targeting driven by supplementary interactions in vitro

Complementarity to the microRNA (miRNA) seed region has long been recognized as the primary determinant in target recognition by the Argonaute-miRNA complex. Recently, we reported that pairing to miRNA 3′-supplementary region (nucleotides 13–16) can increase target affinity by more than an order of...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RNA
Prif Awduron: Xiao, Yao, MacRae, Ian J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961540/
https://ncbi.nlm.nih.gov/pubmed/31732536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.072264.119
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