Gd(3+)-1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic-2-Hydroxypropyl-β-Cyclodextrin/Pluronic Polyrotaxane as a Long Circulating High Relaxivity MRI Contrast Agent

A multivalent magnetic resonance imaging agent based on a 2-hydroxypropyl-β-cyclodextrin (HPCD):Pluronic F127 polyrotaxane carrier has been synthesized and its blood pool contrast properties characterized. This Gd(3+)-DO3A-HPCD/Pluronic polyrotaxane construct is shown to circulate for more than 30 m...

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Publicado en:ACS Appl Mater Interfaces
Autores principales: Zhou, Zhu xian, Mondjinou, Yawo, Hyun, Seok Hee, Kulkarni, Aditya, Lu, Zheng Rong, Thompson, David H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768309/
https://ncbi.nlm.nih.gov/pubmed/26417911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.5b05393
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